With the advancement of science and technology, the field of quality control of pharmaceutical intermediates is also developing, and many new technologies and methods have emerged. Here are some of the latest technologies:
1. Liquid chromatography-mass spectrometry (LC-MS)
Liquid chromatography-mass spectrometry combines liquid chromatography with mass spectrometry to provide qualitative and quantitative information on sample components. LC-MS technology has the advantages of high sensitivity, good selectivity, and a wide range of applications. It can be used in drug analysis, metabolic research, pharmacokinetic research, and other fields. In addition, LC-MS technology is constantly developing, such as ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS), tandem mass spectrometry (MS/MS), etc. These new technologies further improve the sensitivity, selectivity and scope of application of LC-MS technology.
2. Gas chromatography-mass spectrometry (GC-MS)
Gas chromatography-mass spectrometry combines gas chromatography with mass spectrometry to provide qualitative and quantitative information on sample components. GC-MS technology has the advantages of high sensitivity, good selectivity and wide application range, and can be used in drug analysis, metabolic research, environmental monitoring and other fields. GC-MS technology is constantly developing, such as fast gas chromatography-mass spectrometry technology (Fast GC-MS), multidimensional gas chromatography-mass spectrometry technology (GC×GC-MS), etc. These new technologies further improve the sensitivity, selectivity and application range of GC-MS technology.
3. Capillary electrophoresis-mass spectrometry technology (CE-MS)
Capillary electrophoresis-mass spectrometry technology combines capillary electrophoresis technology with mass spectrometry technology to provide qualitative and quantitative information on sample components. CE-MS technology has the advantages of high sensitivity, good selectivity and wide application range, and can be used in drug analysis, metabolic research, proteomics research and other fields. CE-MS technology is constantly developing, such as microcapillary electrophoresis-mass spectrometry technology (CE-MS), nanocapillary electrophoresis-mass spectrometry technology (nCE-MS), etc. These new technologies further improve the sensitivity, selectivity and application range of CE-MS technology.
4. Polymerase chain reaction (PCR) and its derivative technologies
The application of polymerase chain reaction and its derivative technologies in the quality control of pharmaceutical intermediates is becoming more and more extensive. These technologies can be used to detect specific DNA sequences in intermediates, or to quantitatively detect specific RNA or DNA sequences in intermediates by real-time quantitative PCR (qPCR). These technologies are very useful for detecting and quantifying microbial contamination, genetically modified ingredients, etc. in intermediates.
The above are some of the latest technologies in the field of quality control of pharmaceutical intermediates. The application of these technologies not only improves the efficiency and accuracy of quality control, but also provides strong support for the research and development and production of new drugs.