Drug Interactions Of Levofloxacin

1. Urinary alkaline agents can reduce the solubility of this product in urine, leading to crystalline urine and nephrotoxicity.
2. When quinolone antibiotics are used in combination with theophylline antibiotics, the competitive inhibition of the binding site with cytochrome P450 may lead to a significant decrease in the liver elimination of theophylline drugs, an extended half-life of blood elimination (t1/2), an increase in blood drug concentration, and symptoms of theophylline poisoning, such as nausea, vomiting, tremor, unease, agitation, convulsions, palpitations, etc. Although this product has a small impact on the metabolism of theophylline, when used in combination, the blood concentration of theophylline drugs should still be measured and the dosage adjusted.
3. When combined with cyclosporine, this product can increase the blood concentration of cyclosporine. It is necessary to monitor the blood concentration of cyclosporine and adjust the dosage.
4. When used in combination with the anticoagulant drug warfarin, although the anticoagulant effect of the latter is slightly enhanced, the patient's prothrombin time should also be closely monitored when used in combination.
5. Propofol can reduce the secretion of this product from renal tubules by about 50%, and when combined, it can cause toxicity due to increased blood concentration of this product.
6. This product can interfere with the metabolism of caffeine, leading to a decrease in caffeine elimination and a half-life of blood elimination (t1/2 β） Prolonged and may cause central nervous system toxicity.
7. Acid making drugs and iron preparations containing aluminum and magnesium can reduce the oral absorption of this product and should not be used together.
8. When this product is used in combination with the non steroidal anti-inflammatory drug Fenbufen, occasional convulsions may occur, so it is not recommended to use it in combination with Fenbufen.