Adverse reactions to simvastatin

Simvastatin is generally well tolerated, with most adverse reactions being mild and transient. In clinical controlled trials, less than 2% of patients stopped taking simvastatin due to adverse reactions.
In clinical trials with existing control groups, the incidence of adverse reactions (classified as possible, suspicious, or certain) related to drugs is greater than or equal to 1%, including abdominal pain, constipation, and gastrointestinal bloating. Adverse reactions with an incidence of 0.5% to 0.9% include fatigue, weakness, and headache. Reports of myopathy are rare.
The following adverse reactions have been reported in uncontrolled clinical trials or post market applications, such as nausea, diarrhea, rash, indigestion, itching, hair loss, dizziness, muscle spasms, myalgia, pancreatitis, sensory abnormalities, peripheral neuropathy, vomiting, and anemia; Rhabdomyolysis and hepatitis/jaundice are rare occurrences.
There are few reports of obvious allergic response syndromes that include one or more of the following characteristics, such as angioneurotic edema, lupus like syndrome, rheumatic multiple myalgia, vasculitis, thrombocytopenia, eosinophilia, increased erythrocyte sedimentation rate (ESR), arthritis, joint pain, urticaria, photosensitivity, fever, flushing, dyspnea, and discomfort.