Indications for simvastatin

1. Hyperlipidemia:
(1) For patients with primary hypercholesterolemia, heterozygous familial hypercholesterolemia, or mixed hypercholesterolemia, simvastatin can be used to reduce elevated total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and triglycerides when dietary control and other non pharmacological treatments are not ideal. And simvastatin increases high-density lipoprotein cholesterol, thereby reducing the ratio of low-density lipoprotein/high-density lipoprotein and total cholesterol/high-density lipoprotein.
(2) For patients with homozygous familial hypercholesterolemia, simvastatin can be used to reduce elevated total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B when dietary control and non dietary therapy are not ideal.
2. Coronary heart disease. For patients with coronary heart disease, simvastatin is used to:
(1) Reduce the risk of death.
(2) Reduce the risk of death from coronary heart disease and non fatal myocardial infarction.
(3) Reduce the risk of stroke and transient cerebral ischemia.
(4) Reduce the risk of myocardial revascularization surgery (coronary artery bypass grafting and percutaneous balloon coronary angioplasty).
(5) Delay the progression of atherosclerosis, including the occurrence of new lesions and total occlusion.