Oral absorption is rapid but incomplete during fasting, about 30% to 40% of the dose, widely distributed in various tissues and body fluids, such as liver, kidney, lung, prostate, testicles, uterus and bile, sputum, vesicular fluid, blood, urine, etc., but not seen.
The central nervous system. The serum protein binding rate is 10% to 15%, the blood elimination half-life (t1/2) is 3 to 4 hours, and the renal function can be extended to 6 to 9 hours. After a single oral administration of 400mg and 800mg, the peak blood concentration reached 1 ~ 2 hours, and the peak blood concentration (cmax) was 1.4 ~ 1.6mg/L and 2.5mg/L, respectively. The kidney (glomerular filtration and renal tubule secretion) and hepatobiliary system are the main excretion routes, 26% to 32% are excreted in the urine in the original form and less than 10% in the form of metabolites, and 28% to 30% are excreted from bile and/or feces.
Urine pH affects the solubility of the product. Urine dissolved least at pH7.5 and more at other pH levels.
Norfloxacin pharmacokinetics
Nov 04, 2023Leave a message
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