Pharmacology and toxicology of norfloxacin

Fluoroquinolone antibacterial drugs, with a broad spectrum of antibacterial action, especially against aerobic gram-negative bacteria high antibacterial activity, against the following bacteria in vitro has a good antibacterial action: Most of the bacteria in the Enterobacteriaceae family, including E. coli, E. cloacae, E. aerogenes, E. coli, Klebsiella, Proteobacteria, Salmonella, Shigella, Vibrio, Yersinia, etc. Norfloxacin also has antibacterial activity against multi-drug resistant bacteria in vitro. The penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Moraxella catarrh also have good antibacterial effects. Norfloxacin is A bactericide that causes bacterial death by inhibiting DNA synthesis and replication by acting on the A subunit of bacterial DNA helicase.