Pharmacokinetics Of Moxifloxacin Hydrochloride

Moxifloxacin can be quickly and almost completely absorbed after oral administration. The total absolute bioavailability is about 91%. The pharmacokinetics showed a linear relationship between a single dose of 50-1200mg and a daily continuous dose of 600mg for 10 days. Stable state within 3 days. After taking 400mg orally, it reaches a peak of 3.1mg/L within 0.5-4 hours. After taking 400mg orally once a day, the peak and valley concentrations reached steady state at 3.2mg/L and 0.6mg/L, respectively. Providing moxifloxacin with simultaneous consumption can slightly prolong the peak time by about 2 hours and reduce the peak concentration by about 16%. The absorption range remains unchanged. Due to the fact that AUC/MIC mainly predicts the antibacterial effect of quinolone, which is not clinically relevant, the administration of moxifloxacin is not affected by food consumption.
A single dose of 400mg was administered intravenously, and after 1 hour, the peak blood concentration was about 4.1mg/L, an average increase of 26% compared to oral administration. The area under the drug exposure curve is approximately 39 mgh/L, which is slightly higher than oral administration with an absolute bioavailability of about 91% (35 mgh/L). Multi dose intravenous administration (1 hour infusion), with daily 400mg of stable peak and valley concentrations ranging from 4.1 to 5.9 and 0.43 to 0.84mg/L, respectively. The steady-state drug exposure during the dosing interval is approximately 30% higher than the first dose. After one hour of infusion, the patient's steady-state concentration was observed to be 4.4mg/L.