Pharmacological Effects Of Levofloxacin

This product is a levorotatome of ofloxacin, and its in vitro antibacterial activity is about twice that of ofloxacin. Its mechanism of action is to inhibit the activity of bacterial DNA helicase, prevent the synthesis and replication of bacterial DNA, and lead to bacterial death.
Levofloxacin and Shuanghuanglian injections have serious adverse reactions.
The National Center for Adverse Drug Reaction Monitoring has released the latest issue of the "Adverse Drug Reaction Information Notification", reminding medical institutions, medical staff, and drug production and operation enterprises to be vigilant against serious adverse reactions of levofloxacin injection and Shuanghuanglian injection. It is reported that serious adverse reactions/events of levofloxacin injection are mainly systemic damage, central and peripheral nervous system damage, skin and its accessories damage, respiratory system damage, gastrointestinal system damage, among which allergic reaction problems are more typical, with clinical manifestations mainly including allergic shock, allergic like reactions, breathing difficulties, multiform erythema type drug rash, laryngeal edema, etc. In the database of the National Center for Adverse Drug Reaction Monitoring, the analysis of serious case reports of levofloxacin injection indicates that the product has clinical unreasonable use, and some unreasonable drug use issues have become the main factors causing serious adverse events. As clearly stated in the instructions for levofloxacin injections, it is prohibited for patients under the age of 18.